Skip to main content

Nimesulide

 

1. Generic Name & Brand Names

  • Generic Name: Nimesulide

  • Brand Names (Regional):

    • Europe: Mesulid®, Aulin® (suspended in many countries)

    • Asia: Nise®, Nimulid® (India), Nimed®

    • LATAM: Scaflam®

    • Not approved in USA/Canada/UK/Australia

2. Dosage Forms

  • Oral:

    • Tablets (50 mg, 100 mg)

    • Dispersible tablets/granules

    • Suspension (50 mg/5ml)

  • Topical:

    • Gel (3%)

    • Cream

3. Drug Class

  • NSAID with preferential COX-2 inhibition

  • Analgesic, Anti-inflammatory, Antipyretic

4. Uses

  • Short-Term (<15 days) Acute Pain:

    • Musculoskeletal pain (sprains, backache)

    • Dental pain, Post-traumatic inflammation

    • Primary dysmenorrhea (period pain)

  • Not for chronic conditions (e.g., arthritis)

5. Side Effects

Common (≥1%)Serious (STOP + Seek Help)
Heartburn, nauseaHepatotoxicity (jaundice, liver failure)
DiarrheaSevere Skin Reactions (SJS/TEN)
DizzinessGastrointestinal Bleeding
Pruritus (itching)Acute Kidney Injury
RashAnaphylaxis (throat swelling)

6. Critical Warnings

  • ⚠️ Hepatotoxicity Risk:

    • 1,000 cases of liver damage reported globally

    • Banned in EU/UK/Australia/NZ; restricted in India (max 15 days)

  • Absolute Contraindications:

    • Liver disease or elevated LFTs

    • Alcoholism

    • Kidney disease

    • Pregnancy/breastfeeding

    • Children <12 years

  • Drug Interactions:

    • Warfarin (↑ bleeding risk)

    • Diuretics (↑ kidney damage)

    • Other NSAIDs (↑ toxicity)

7. How to Take

  • Dose: 100 mg twice daily (max 200 mg/day)

  • Duration: ≤15 days (strict limit)

  • With Food: Always take after meals

  • Topical Gel: Apply 3-4x daily (max 4 weeks)

  • Never exceed recommended dose!

8. Uses in Adults

  • Acute inflammatory pain only

  • Never for fever or chronic pain

  • Avoid in patients >65 years

9. Missed Dose

  • Skip if >2 hours late

  • Never double dose

10. Overdose

  • Symptoms:

    • Vomiting, stomach bleeding, seizures, liver failure

  • Action:

    • Emergency hospitalization required

    • No specific antidote - supportive care only

11. Avoid While Taking

  • Alcohol (↑ liver failure risk)

  • Other NSAIDs (diclofenac, aceclofenac)

  • Anticoagulants (heparin, apixaban)

  • Corticosteroids (prednisone)

12. Storage

  • Temperature: Below 30°C (86°F)

  • Protect from moisture

  • Keep away from children (100 mg = lethal dose for child)

🔴 Critical Safety Alerts:

  1. Liver Failure Risk:

    • Monitor LFTs before and during treatment (if used)

    • Discontinue if:

      • Dark urine / yellow eyes/skin

      • Fatigue / abdominal pain

  2. Banned/Restricted Status:

    • Suspended in 50+ countries due to safety concerns

    • Only use if safer alternatives (e.g., ibuprofen) fail

  3. Maximum 15-Day Rule:

    • Never exceed 15 days of continuous use

Global Regulatory Status:

  • ❌ Banned: EU, UK, Australia, Canada, Japan

  • ⚠️ Restricted: India, Brazil (max 15 days, prescription-only)

  • ❌ Not approved: USA

Consult your doctor before use - Safer NSAIDs (e.g., ibuprofen) are preferred for short-term pain.


Comments

Post a Comment

Popular posts from this blog

First-Year BPT Study Guide: Units 1 to 4 Explained for Physiotherapy Students

  🔹 Introduction Starting your Bachelor of Physiotherapy (BPT) journey? The first year lays the essential groundwork for becoming a skilled physiotherapist. This blog explains the first-year BPT Units 1 to 4—key concepts that cover physiotherapy basics, anatomy, physiology, and professional ethics. Whether you're studying for exams or building your foundation, these insights are crucial for academic and clinical success. 🔹 Unit 1: Introduction to Physiotherapy Keywords: introduction to physiotherapy, first-year physiotherapy course, BPT basics In this unit, students explore the history, scope, and branches of physiotherapy. From treating joint pain to supporting neurological rehabilitation, physiotherapy offers diverse career opportunities. The profession originated in ancient times and gained formal recognition during wartime rehabilitation. Specialties include: Orthopedic physiotherapy Neurological physiotherapy Pediatric physiotherapy Cardiopulmonary physiot...
Post a Comment
Read more

🔌 Galvanic vs Faradic Currents: Key Differences for Students

 Electrotherapy is a powerful tool in physiotherapy — and two of its foundational currents are Galvanic and Faradic currents. Whether you're studying for exams or brushing up for clinical practice, here's a clear breakdown to help you understand the key differences between the two. ⚡ What Are They? 🔌 Galvanic Current Also called Direct Current (DC) , this is a continuous, unidirectional flow of electric charge. It has a constant polarity (positive and negative electrodes). Type: Continuous Direct Current (DC) Polarity: Fixed (positive/negative) Used for: Iontophoresis Wound healing Stimulation of denervated muscles 🔄 Faradic Current This is an Interrupted or Pulsed Alternating Current (AC) , with short duration and high frequency. It mimics natural nerve impulses to stimulate muscles. Type: Interrupted Pulsed AC Polarity: No fixed polarity Used for: Muscle re-education Improving muscle tone Treating muscle atrophy in parti...
Post a Comment
Read more

⚠️ Contraindications of Electrotherapy Modalities: Learn Fast

  Electrotherapy is a powerful tool in physiotherapy — but using it safely is just as important as using it effectively. Here's a fast-track guide to the contraindications of common electrotherapy modalities for students, interns, and clinicians. 🚫 What Are Contraindications? These are conditions or situations where electrotherapy should NOT be used due to risk of harm or complications. ⚡ Common Electrotherapy Modalities & Their Contraindications 🔌 1. TENS (Transcutaneous Electrical Nerve Stimulation) Avoid if: Patient has a pacemaker or implantable defibrillator Over pregnant abdomen or uterus Over malignant tumors Broken, infected, or anesthetic skin On carotid sinus area (risk of cardiac reflex) Epileptic patients (caution advised) 🔄 2. IFT (Interferential Therapy) Avoid if: Metal implants in the treatment area Open wounds or skin conditions Pregnancy (especially lower abdomen/lumbar) Over the eyes, carotid sinus, or chest...
Post a Comment
Read more